Here's a new idea I was just thinking about:
The mother of God (played by some curmudgeonly old lady): She lives in a pretty run down little trailer home in north eastern Califonia. She grows weed. She has a cat and a three legged dog simply named Kitums and Pooch. When not at home she is at the local coffee shop or bar to talk about how messed up her son is, but no one believes her they all just think she is crazy.
One day God (played by someone like Jason Lee or David Cross) shows up to steal some of his mom's weed but gets caught and pretends he was there to surprise his mom for dinner. At dinner He asks about who his dad is. That question gets his mom all upset but eventually she tells him that she's not quite sure who his dad is but she has some old photos of who he might be and she decides to help him find God's dad (who will be played by someone like the Dude, Jeff Bridges). God decides to stay in California for a while to search for his dad with his mom.
Within the first few episodes God's dad is found and, as would be expected based on the character of God, his dad is a dead beat as well. Though strangely neither of God's parents have the same magical abilities as God himself except that they live forever and have been around for all eternity, but that doesn't really matter because God is so lethargic, apathetic, and kind of stupid that he never uses his powers wisely or at all.
The show is narrated by God's mother.